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BMC Biochemistry

Featured article: An evolutionary encounter between tRNA and myelin maturation

tRNA splicing is an essential process in the maturation of eukaryotic pre-tRNA molecules. This study shows that tRNA healing enzymes from yeast and lancelet share structural and functional properties with members of the 2H-phosphoesterase superfamily, in particular the vertebrate myelin enzyme CNPase. While domain organization has been conserved, functions of the individual domains may have been altered or lost during evolution.

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Featured article: Essential residues of Dnmt3a

The conserved residues of Dnmt3a, R200 and R202, are essential for methylation activity. They are involved in positioning of the flipped target base and in creating and stabilizing of the transient covalent intermediate of the methylation reaction.

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2. METHODOLOGY ARTICLE

   Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase

   Arina Marina Perez, Bruno Aquino, Vadim Viviani and Jörg Kobarg

   Published on: 19 July 2017
3. RESEARCH ARTICLE

   Dacin, one metalloproteinase from Deinagkistrodon acutus venom inhibiting contraction of mouse ileum muscle

   Bin Zhou, Gang Liu, Qiyi He, Bo Li and Xiaodong Yu

   Published on: 12 July 2017
4. RESEARCH ARTICLE

   Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

   Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore and Daniel S. Sem

   Published on: 31 May 2017
5. RESEARCH ARTICLE

   Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem

   Mario A. Bianchet, Ying H. Pan, Leighanne A. Brammer Basta, Harry Saavedra, Evan P. Lloyd, Pankaj Kumar, Rohini Mattoo, Craig A. Townsend and Gyanu Lamichhane

   Published on: 25 May 2017
6. RESEARCH ARTICLE

   Chemical and structural characterization of α-N-acetylgalactosaminidase I and II from starfish, asterina amurensis

   Md. Harun-Or Rashid, Golam Sadik, AHM Khurshid Alam and Toshihisa Tanaka

   Published on: 25 May 2017

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