Classifying Gastric Cancers by Subtype May Provide Tailored Treatment Options

By Jo Cavallo
Posted: 7/27/2017 9:45:31 AM
Last Updated: 7/27/2017 9:45:31 AM

Key Points

The molecular classification of the four distinct subtypes of gastric cancer—Epstein-Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN)—may potentially provide tailored treatment options by helping to predict survival outcomes and patients’ response to chemotherapy.
Overall, the EBV subtype was associated with the best prognosis for both recurrence-free and overall survival, and the GS subtype was associated with the worst prognosis. Patients with MSI and CIN subtypes had poorer overall survival than those with the EBV subtype but better overall survival than those with the GS subtype.