Data from the Creatine Safety, Tolerability & Efficacy in Huntington’s Disease (CREST-E) trial show that the dietary supplement creatine, in doses up to 40 mg daily for as long as 4 years, does not slow progression of the disease in people with early symptoms. This trial, supported by the National Center for Complementary and Integrative Health (NCCIH), with additional funding from the National Institutes of Health’s Office of Dietary Supplements, was recently published in the journal Neurology.
Huntington’s disease is an inherited neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive disturbances. No treatment has been shown to slow its progression.
CREST-E began enrolling participants in 2009; it was halted in 2014 after 553 men and women with early symptomatic Huntington’s disease had joined it at 46 sites in North America, Australia, and New Zealand. The study was stopped early as results from the first planned interim analysis revealed that further treatment and followup in the trial would not show a beneficial effect of creatine in delaying functional neurologic decline.
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