lunes, 7 de agosto de 2017

Review of the current medical literature and assessment of current utilization patterns regarding mismatch repair protein immunohistochemistry in c... - PubMed - NCBI

Review of the current medical literature and assessment of current utilization patterns regarding mismatch repair protein immunohistochemistry in c... - PubMed - NCBI





 2017 Jul 27. doi: 10.1111/cup.13010. [Epub ahead of print]

Review of the current medical literature and assessment of current utilization patterns regarding mismatch repair protein immunohistochemistry in cutaneous Muir-Torre syndrome-associated neoplasms.

Abstract

Muir-Torre syndrome is a clinical variant of Lynch syndrome defined by the synchronous or metachronous occurrence of at least one sebaceous neoplasm and at least one Lynch syndrome-related internal cancer. Although screening guidelines for patients with colorectal carcinomas have been established, screening guidelines for cutaneous Muir-Torre associated neoplasms are not currently available. As such, we reviewed the current evidence for the use of MLH1, MSH2, MSH6, and PMS2 immunohistochemistry when cutaneous Muir-Torre associated neoplasms are encountered. We identified weak to moderate support overall for the global use of these assays, with some evidence suggesting a tailored approach using clinical parameters as an adjunct. We also assessed the current utilization patterns of attendees of the American Society of Dermatopathology Annual Meeting (Chicago, 2016). We found that 91% of respondents utilize mismatch repair immunohistochemistry, with the majority utilizing these tests only when requested by the submitting clinician.

KEYWORDS:

Immunohistochemistry; In situ hybridization; Muir-Torre Syndrome

PMID:
 
28749576
 
DOI:
 
10.1111/cup.13010

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