Genetics of Prostate Cancer (PDQ®)–Health Professional Version

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Changes to This Summary (11/02/2017)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Identifying Genes and Inherited Variants Associated With Prostate Cancer Risk

Added text about a 2016 analysis of a collection of risk variants that suggested an association between cumulative risk allele status and early-onset prostate cancer (cited Lange et al. as reference 207).

Genes With Potential Clinical Relevance in Prostate Cancer Risk

Added text about research that is under way to gain insight into the biologic basis of aggressive prostate cancer in carriers of BRCApathogenic variants; one study of 14 BRCA2 germline pathogenic variant carriers reported that BRCA2-associated prostate cancers harbor increased genomic instability and a mutational proﬁle that more closely resembles metastatic prostate cancer than localized disease, with genomic and epigenomic dysregulation of the MED12L/MED12 axis similar to metastatic castration-resistant prostate cancer (cited Taylor et al. as reference 34).

Added text about a meta-analysis of 25 studies including 51,390 cases and 93,867 controls that revealed an association between HOXB13 and prostate cancer that was most significant in Caucasians, especially those of European descent; no association was found for breast or colorectal cancer (cited Cai et al. as reference 60).

Added TP53 as a new subsection.

Interventions in Familial Prostate Cancer

Updated Table 10, Summary of Prostate Cancer Screening Recommendations for High-Risk Men, with National Comprehensive Cancer Network (NCCN) 2017 guidelines (cited NCCN as reference 11).

Added Tumor Sequencing to Inform Germline Findings and Targeted Therapies in Prostate Cancer as a new subsection.

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

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Genetics of Prostate Cancer (PDQ®)—Health Professional Version - National Cancer Institute