Obesity

Obesity

Edited by Alessandro Bartolomucci and Fabio Virgili

Obesity and associated diseases (type-2 diabetes [T2D], hypertension, etc.) are rising exponentially to pandemic levels worldwide. Despite major advances in our understanding of the signaling pathways involved in energy homeostasis, we currently possess very few safe and effective therapeutic answers to obesity. Identifying new mechanisms that have the potential to inform about the development of more efficacious and safer drugs represents a major need for society and a challenge for the biomedical field. This latest thematic series in Genes and Nutrition features invited topic reviews by leaders in the field, which focus on established and novel major determinants of the Obesity epidemic such as dietary fat, branched chain amino acids and probiotics, and gene X environment interaction, as well as gut microbiota and microRNA.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections published in Genes and Nutrition.

1. CONTENT TYPE:RESEARCH

   Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition

   Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

   Authors:Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi

   Citation:Genes & Nutrition 2017 12:25

   Published on: 4 October 2017

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2. CONTENT TYPE:REVIEW

   Does dietary fat affect inflammatory markers in overweight and obese individuals?—a review of randomized controlled trials from 2010 to 2016

   Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

   Authors:Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

   Citation:Genes & Nutrition 2017 12:26

   Published on: 4 October 2017

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3. CONTENT TYPE:REVIEW

   Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control

   Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

   Authors:Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

   Citation:Genes & Nutrition 2017 12:27

   Published on: 4 October 2017

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4. CONTENT TYPE:REVIEW

   Role of microRNAs in obesity and obesity-related diseases

   In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

   Authors:Giuseppe Iacomino and Alfonso Siani

   Citation:Genes & Nutrition 2017 12:23

   Published on: 25 September 2017

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5. CONTENT TYPE:REVIEW

   Obesity and microbiota: an example of an intricate relationship

   It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

   Authors:Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni

   Citation:Genes & Nutrition 2017 12:18

   Published on: 15 June 2017

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