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BMC Pharmacology and Toxicology

Featured article: Tolerance to NSAIDS and opioids in the brain

Chronic NSAID administration in the anterior cingulate cortex can produce analgesic effects and chronic administration can result in tolerance. The authors also find that the effects of NSAIDs in the brain are mediated by the opioid system. 

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1. Content Type:Research Article

     |  21 February 2018

   A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

   Authors:Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis and Teodorico C. Ramalho
2. Content Type:Research Article

     |  13 February 2018

   Tomatidine and analog FC04–100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp

   Authors:Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault and François Malouin
3. Content Type:Case Report

     |  13 February 2018

   A case report of clonidine induced syncope: a review of central actions of an old cardiovascular drug

   Authors:Alexander J. Sandweiss, Christopher M. Morrison, Anne Spichler and John Rozich
4. Content Type:Research Article

     |  31 January 2018

   Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway

   Authors:I-Yun Lee, Yin-Yin Lin, Yao-Hsu Yang, Yu-Shin Lin, Chun-Liang Lin, Wei-Yu Lin, Yu-Ching Cheng, Li-Hsin Shu and Ching-Yuan Wu
5. Content Type:Research Article

     |  25 January 2018

   A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

   Authors:Hyun-moon Back, Byungjeong Song, Sudeep Pradhan, Jung-woo Chae, Nayoung Han, Wonku Kang, Min Jung Chang, Jiao Zheng, Kwang-il Kwon, Mats O. Karlsson and Hwi-yeol Yun

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