Dr. Takayuki Koyano Dr. Makoto Matsuyama
Dr. Takayuki Koyano is a researcher in the Division of Molecular Genetics at Shigei Medical Research Institute. He obtained his PhD from Hiroshima University under the supervision of Dr. Dai Hirata. He then moved to London where he undertook a post-doctoral project in Dr. Takashi Toda’s lab at the Francis Crick Institute/LRI. His current research pursues the molecular mechanisms of kidney diseases.
Dr. Makoto Matsuyama is a principal investigator of the Division of Molecular Genetics at Shigei Medical Research Institute. He completed his PhD at the National Institute for Basic Biology and joined at the Center for Developmental Biology (CDB) and the Aichi Cancer Center Research Institute as postdoc. He established the rGONAD method for generating genome-edited rats. His scientific goal is to understand kidney development and pathology using genetic approaches.
Dr. Makoto Matsuyama is a principal investigator of the Division of Molecular Genetics at Shigei Medical Research Institute. He completed his PhD at the National Institute for Basic Biology and joined at the Center for Developmental Biology (CDB) and the Aichi Cancer Center Research Institute as postdoc. He established the rGONAD method for generating genome-edited rats. His scientific goal is to understand kidney development and pathology using genetic approaches.
rGONAD: A new simple method for genome-editing in rats
Genome edited animals are important in the study of a whole host of scientific fields. Now new research published in BMC Biotechnology takes a novel method for genome editing in mice and successfully applies it to rats, another important animal model. Here, the authors of this study highlight the functional and ethical benefits of this new method.
Genome-edited animals are widely used in various fields of research. Recent advances in the field of genome-editing, especially the CRISPR/Cas9 system (Clustered Regulatory Interspaced Short Palindromic Repeats /CRISPR associated protein), have enabled rapid generation of genome-edited animals with ease. However, the procedure for producing such animals involves multiple complicated steps and also necessitates special techniques, such as handling zygotes ex vivo. Many researchers desire a simple and convenient method for generating genome-edited animals.
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